The inhibition of the malignant potential by targeting tumor cell-derived exosomes in oral squamous carcinoma cells

The inhibition of the malignant potential by targeting tumor cell-derived exosomes in oral squamous carcinoma cells

山本哲也(Tetsuya YAMAMOTO)

Professor and Chairman, Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University

Exosomes are 30-100 nm-sized membranous vesicles, secreted from a variety of cell types into their surrounding extracellular space. Various exosome components including lipids, proteins, and nucleic acids are transferred to recipient cells and affect their function and activity. Numerous studies have showed that tumor cell-derived exosomes play important roles in tumor growth and progression. However, the effect of exosomes released from oral squamous cell carcinoma (OSCC) into the tumor microenvironment remains unclear. In the present study, we isolated exosomes from OSCC cells and investigated the influence of OSCC cell-derived exosomes on the tumor cell behavior associated with tumor development. We demonstrated that OSCC cell- derived exosomes were taken up by OSCC cells themselves and significantly promoted proliferation, migration, and invasion through the activation of the PI3K/Akt, MAPK/ERK, and JNK-1/2 pathways in vitro. These effects of OSCC cell-derived exosomes were obviously attenuated by treatment with PI3K, ERK-1/2, and JNK- 1/2 pharmacological inhibitors. Furthermore, the growth rate of tumor xenografts implanted into nude mice was promoted by treatment with OSCC cell-derived exosomes. The uptake of exosomes by OSCC cells and subsequent tumor progression was abrogated in the presence of heparin. Taken together, these data suggest that OSCC cell-derived exosomes might be a novel therapeutic target and the use of heparin to inhibit the uptake of OSCC-derived exosomes by OSCC cells may be useful for treatment.

Curriculum Vitae

1979-1985 Tokushima University Faculty of Dentistry
1985- Kochi Medical School Hospital
1986- Otsuki Hospital
1987- Instructor, Kochi Medical School Hospital
1993- Senior Lecturer, Kochi Medical School Hospital
2000- Associate Professor, Kochi Medical School Hospital
2002-2003 Visiting Scientist, Medical College of Georgia, USA
2004- Professor and Chairman, Kochi Medical School, Kochi University

Two jaw surgery using CAD/CAM wafer based on soft tissue 3D simulation

Two jaw surgery using CAD/CAM wafer based on soft tissue 3D simulation

富永和宏(Kazuhiro TOMINAGA) 九州歯科大学 Kyushu Dental University The goal of orthognathic surgery is to harmonize optimal aesthetic features with functional occlusion. To achieve this goal, precise morphological and functional analyses as well as optimal planning of the final goal during pre-surgical treatment is mandatory. Additionally, accurate reproduction of the simulated goal during operation is necessary. Conventional pre-surgical planning has been made with 2D cephalometric prediction. However, to achieve optimum aesthetic and occlusal results, 3D planning is going to be necessary. Especially in facial asymmetry cases which need surgical correction of not only pitch and roll but yaw, 3D simulation is mandatory. In this paper, I'm going to present two jaw surgery using intermediate wafer fabricated by CAD/ CAM based on soft tissue 3D simulation in facial asymmetry cases. Gross planning mainly relating the surgical correction of pitch and roll of the maxilla is followed by 2D analyses. The data are introduced to 3D virtual surgery program (SimPlant Pro OMS 10.1; Materialise Leuven, Belgium). Soft tissue surface reconstruction after virtual surgery is visually evaluated by some orthodontists and oral surgeons. Then little by little correction of yaw in the software is tested maintaining facial midline. The repositioning position of the maxilla in the best aesthetic feature judged by evaluators is the final goal of the operation. In this position of the maxilla, intermediate wafer is fabricated using CAD/CAM. This method can eliminate many time-consuming laboratory steps. Additionally it can reduce technical errors derived from manual preparation ie, face bow transfer, manual reposition of the plaster cast etc. I will present the accuracy of the method comparing virtual surgery and CT taken after the operation.

Osteosarcoma of the jaws in Koreans: analysis of 26 cases

Osteosarcoma of the jaws in Koreans: analysis of 26 cases 金亨埈(Hyung-Jun KIM) Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, Korea Objective: In order to assess clinical behavior, response to treatment, and factors influencing prognosis of patients with osteosarcoma of the jaws (OSJ) in Koreans. Methods: A retrospective study of clinical, pathological, and histological records was undertaken for 26 patients with OSJ treated at the department of Oral and maxillofacial surgery in Yonsei University Dental Hospital from 1990 to March, 2016. Result: Out of 26 patients studies, there were 9 men (34.6%) and 17 women (65.4%). Twentyone of 26 patients had osteosarcoma of the mandible, and 5 of 26 patients had osteosarcoma of maxilla. The histopathology of OSJ is highly variable, ranging from chondroblastic type (6 patients out of 26), osteoblastic type (10 patients out of 26), fibroblastic type (2 patients out of 26), to the rare variants like mixed type and small cell osteoscarcoma types among others. All patients underwent gross total excision and only few patients underwent the neoadjuvant chemotherapy. Postoperative chemotherapy was given to most of the patient as adjuvant or in combination with radiotherapy. The overall survival rate was 73.1% with a overall 2-yeaer survival rate of 83.3%. The overall 5-,10-,15-year survival rates in this study were 73.5%, 73.5%, 49%, respectively. Using Kaplan-Meier analysis with log rank tests, the size of tumor (T-stage), and resection margins were found to affect the survival rate significantly. The chemotherapy was not significantly associated with improved survival rate. Conclusion: Surgical resection with clear margin is the most important factor in disease survival. The role for chemotherapy and radiotherapy in osteosarcoma of the jaws remains controversial, which deserves further studies. Curriculum Vitae Graduated from Yonsei University College of Dentistry and took one year Internship and three year Residency, and two year Fellowship in Oral and Maxillofacial Surgery at Yonsei University Health System. Received Doctor of Dental Surgery and Master of Science in Dentistry degrees in Yonsei University and Dr. med. dent. degree in Ludwig-Maximilians University, Munich, Germany. Visiting Scholar, Oral and Maxillofacial Surgery, Ludwig-Maximilians University, Munich, Germany. (Oct. 1997 - Sep. 1999)–6–

Visiting Professor, Institute of Surgical Experiment, Ludwig-Maximilians University, Munich, Germany. (Feb. 2006 - Jan. 2007) Visiting Professor, Oral and Maxillofacial Surgery, Tokyo Dental College, Japan. (Jun. 2008) Visiting Professor, Oral and Maxillofacial Surgery, Technical University of Munich, Germany. (Oct. 2013) Professor and Chairman in Oral and Maxillofacial Surgery, Yonsei University College of Dentistry. Adjunct Professor in Oral Biology, Yonsei University College of Dentistry Director of Education and Research, Yonsei University Dental Hospital Research Ambassador, German Academic Exchange Service Secretary General, Korean Association of Oral and Maxillofacial Surgeons

My Modified Surgical Tips from Original Orthognathic Procedures -Experience-based Suggestion

My Modified Surgical Tips from Original Orthognathic Procedures -Experience-based Suggestion

金 容德教授　(Professor Yong-Deok KIM)

Department of Oral and Maxillofacial Surgery, School of Dentistry,

Pusan National University, KOREA

Orthognathic surgery is procedure designated to correct conditions of the jaw and face related to structure, growth, sleep apnea, TMJ disorders, malocclusion problems owing to skeletal disharmonies or other orthodontic needs. It has been well documented in the numerous texts and very familiar with recent oral and maxillofacial surgeons all around the world. Each step of the procedure is clearly noticed with proper reason and purposes and guaranty the safe surgery. But some surgeons might modify any step for their own object under their experiences and sometimes the modified step was very useful, reliable and reasonable even they were not commented in any text or article. The present presentation would introduce and suggest my tips which were used practically during my orthognathic surgery. The following modified procedures are part of my tips which are going to mention to the audience.

1. Out-fracture of inferior turbinate
2. Intentional fracture of pterygoid plate
3. Swing cinch
4. Effective exposure of descending palatine artery

I don't think those procedures are evidence-based but hope they might be the useful idea or applied to the audience's daily surgery.

Curriculum Vitae
Professor, Dept. of OMFS, School of Dentistry, Pusan National University, KOREA
Head, Dept. of OMFS, Pusan National University Dental Hospital
Director, Institute of Translational Dental Sciences, Pusan National University, KOREA
Director, Institutional Review Board(IRB) of Pusan National University Dental Hospital
Fellow, International Team for Implantology(ITI)
(former) Visiting Scholar, Dept. of 1st OMFS, School of Dentistry, Kyushu University, JAPAN
(former) Postdoctoral Fellow, Dept. of OMFS, Faculty of Dentistry, Univ. of Toronto, CANADA

會員大會Assembly

 17:10 - 17:40 

International Convention Center

Chorus KMU Singers

16:40 - 17:10

高雄醫學大學 聲樂社

Kaohsiung Medical University Singers

陳俊志醫師指揮

Conducted by Dr William Chun-Chih CHEN, DDS

曲目

童年       Childhood        子供時代

苦行的路 Ascentic Road アスケチックロード

台灣        Taiwan            台湾

Rhinoplasy and Orthognathic Surgery on the Patients with Cleft Lip and Palate by Prof Tsuyoshi TAKATO

Rhinoplasy and Orthognathic Surgery  on the Patients with Cleft Lip and Palate 高戶毅(Tsuyoshi TAKATO)  University of Tokyo Hospital, JAPAN

Dept. of Oral and Maxillofacial Surgery Div. of Tissue Engineering JR Tokyo General Hospital

Due to the multidisciplinary approach, the satisfactory results are obtained in the treatment of cleft lip/ palate. 

However, the deformity of nose and maxillomandibular discrepancy in cleft lip/palate patients, has not been solved completely. Our group reported that one of the reasons of the nasal deformity was caused by the deviation of both the septal cartilage and perpendicular plate. Septoplasty and turbinectomy are performed to relieve the obstructed nasal breathing. An adequate-sized piece is cut from the removed cartilage to enforce the columella, which acts as a strut to keep both lower lateral cartilages symmetrical and to create a nasal tip. A common additional request from our Oriental patients is for a narrower nose with a more prominent profile. We prefer the cantilever bone grafting for that purpose. The graft material is the iliac bone. Although the satisfactory results are obtained, the nose that is reconstructed with iliac bone is too hard and some patients experienced the fracture of the grafted bone. Until now, we developed regenerative cartilage for the nose with auricular chondrocytes. The clinical trial has been finished with satisfactory results. Although the poly-L lactic acid scaffold enables auricular chondrocytes to attach and generate cartilage matrix, it has simple shape, limiting the application of this technique to the cartilage defects in other regions. To solve these problems, now we are promoting a project to develop a 3D bioprinter with which cells and growth factors can be injected in addition to scaffold materials. In this project, we will regenerate bone, skin, meniscus, cartilage and knee joint by mimicking both outer shapes and inner structures of native tissues. We are also engaged in research on ear reconstruction using induced pluripotent stem cells (iPS cells). Conventionally, one-stage 2-jaw surgery combining Le Fort I osteotomy and mandibular setback surgery has been used to treat severe maxillomandibular discrepancy in cleft lip/palate patients. In some patients, stable occlusion and a good aesthetic outcome of this method are precluded by the presence of severely contracted soft tissue. Recently, maxillary distraction has been used for midface advancement in such patients. This technique allows the overlying midface to be advanced, because distraction osteogenesis gradually lengthens both the bones and the soft tissues. However, the control of maxillary movement is difficult and the long wearing of outstanding distractors causes psychosocial problems. To overcome these problems, we had developed the two-stage surgery consists of maxillary distraction and mandibular osteotomies.

Curriculum Vitae Career 2017- Present 2011-2017 2001-2017 1996-2017 1992-1996 1989-1992 1987-1989 1985-1987 1983-1984 1979-1983 Education 1973-1979 Director of Hospital of JR Tokyo General Hospital Director of 22nd Century Medical and Research Center Chief of Division of Tissue Engineering Professor of Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of Tokyo Associate Professor of Department of Oral and Maxillofacial Surgery, University of Tokyo Assistant Professor of Department of Oral and Maxillofacial Surgery, University of Tokyo (1990 July - 1991 May Toronto Sick Children's Hospital, Plastic Surgery Division) Chief of Plastic Surgery Division, Shizuoka Sick Children's Hospital Chief of Plastic Surgery Division, Bokuto Metropolitan Hospital Staff of National Cancer Center, Head and Neck Division Residency-Plastic Surgery Division, Tokyo University Hospital and Hyogo Sick Children's Hospital University of Tokyo, Faculty of Medicine (Graduate School)

TW-KR Joint Board Meeting

台韓合同會

한대 합동회

TAOMS-KAOMS Joint Board Meeting

Time: 7:30 -8:30, March 10 ,2018

時間: 2018年3月10日上午7:30- 8:30

시간 : 2018 년 3 월 10 일 오전 7 : 30- 8:30

4F, Jing-Chuen Garden, Ambassador Hotel Kaohsiung

地點: 高雄國賓飯店 4F景春園

장소 : 앰버서더 호텔 카오슝 4F

主持人

l   程 稚盛 監事（國際事務委員會副主任委員・台中榮民總醫院）

Chi-Sheng CHENG (Auditor; Chair in deputy, International Affair Committee; Taichung Veteran General Hospital)

韓國代表 Korean Delegates

Young-Wook PARK朴瑛郁 教授 (President of KAMPR)
 Chul Hwan KIM (President of KAOMS)

 Seung O KO Invited Speaker (Vice President of KAMPRS)

 Yong-Deok KIM Invited Speaker (International Liaison of KAMPRS
金容德 教授 釜山國立大學校

 Hyung Jun KIM Invited Speaker (Secretary Genera l of KAOMS)

 Woong NAM Invited Speaker Planning of KAMPRS

 Kyung-Hwan KWON Invited Speaker Insurance of KAMPRS

 

台灣代表Taiwanese Delegates

  陳 遠謙 理事長 台中 中國醫藥大學

Prof Michael Yuanchien CHEN (President TAOMS, China Medical U, Taichung)

  陳 萬宜 理事（台中榮民總醫院）

Prof Man-Yee CHAN (Council director, Taichung Veteran General Hospital)

  陳 俊明 監事（高雄醫學大學）

Prof Chun-Ming CHEN (Auditor, Kaohsiung Medical U)

  蔡 國陽 理事(彰化基督教病院)

Kuo-Yang TSAI (Council director, Changhua Christian Hospital)
 林 冠州 理事（IAOMS台灣代表／台北萬芳醫院醫學中心）

Charles Kuanchou LIN （Council Director, TPE Municipal WanFang Hospital）
 鄭 世榮 主任委員(學術委員會; 國立台灣大學)

     Prof Elliot Shih-Jung CHENG (Scientific Committee Chair)

     Invited speaker at 59^th KAOMS

  李 曉屏 監事(三軍總醫院/三軍総病院; 國防醫學院)

Shiao-Pieng LEE (Council director, Tri-Service General H, National Defense Medical Center)

 彭 芷瑜 理事 (台中中山醫學大學/台中中山医学大学)

ChiYu PENG (Council director, Chung Shan Medical U, Taichung)

 吳政憲 理事 (國立陽明大學 台北榮民總醫院)

Cheng-Hsien WU (National Yang Ming University, Taipei Veteran General Hospital)

 方致元 主任委員（法制委員會; 台北市立総合医療センター台北萬芳醫院醫學中心）

Chih-Yuan FANG (TPE Municipal WanFang Hospital)

張 明智  秘書長(事務総長；汐止國泰醫院/汐止国泰総合病院)

Ming-Chih CHANG (Secretary in General, Sijhih Cathay General Hospital)

 吳 家佑 理事 (臺北醫學大學/台北医学大学)

Chia-Yu WU (Council director, Taipei Medical U)

 許 博智 監事 (新店慈濟醫學中心／仏教慈済総合病院台北分院)

Po-Chih HSU (Taipei Buddhist Tzu Chi General Hospital
柯 政全 主任委員(國際事務委員會主任委員; 高雄醫學大學)

    Edward Chengchuan KO (International Affair Committee Chair, Kaohsiung Medical U)

Organizing Committee Chair, 2018 Annual Conference of TAOMS 大會籌備會主席

Invited speaker at 59th KAOMS

議程 (Agenda):

1.      Opening welcome message              

Edward Chengchuan KO  (TAOMS國際事務主委/委員長)

2.  Greetings & Introductions by the Presidents (介紹雙方與會成員)         

      Prof Michael Yuanchien CHEN陳 遠謙 理事長&

  Young-Wook PARK (President of KAMPR)

  Chul Hwan KIM (President of KAOMS)

3.      Introduction of Annual Meetings:

 (1)59th Congress of KAOMS, 2018  

  Chul Hwan KIM (President of KAOMS)

会 期：2018年4月26日（Thu）〜 28日（Sat）

会場：Asan Medical Center

Will be held from Apr 26^th-28^th, 2018

Venue: Asan Medical Center

Officially Recommended Speakers from Taiwan will be

鄭世榮 教授 Prof. Shih-Jung CHENG (National Taiwan University)

柯政全      Edward Chengchuan KO (Kaohsiung Medical U)

   (2) Information about 2018 annual meeting of KAMPRS by  

      Young-Wook PARK (President of KAMPRS)

Organizer:

会 期 : 2018年10月25日-27日

会 場 : 大韓民國忠清北道清洲市

      Date: Oct 25- 27^th, 2018

Venue: Cheongju청주시

(3) Information about TAOMS, 2019 by Prof MY CHEN陳遠謙

      2019 TAOMS Will be held in from March 9th-10th, 2019.

      Venue: Fleur de Chine by the Sun Moon Lake

（日月潭雲品溫泉酒店）

      No lectures, no speech, only hot spring and election!!

4.  Information about 2018 ACOMS hosted by TAOMS, by Prof. 陳遠謙

5.  Free discussion

6.  Closing message 

柯 政全Edward Chengchuan KO  (TAOMS國際事務主委)

7.  Group Photo

Oral Presentation

Oral presentation
March 10 / Meeting Room A
Moderator: 楊政杰 / 吳家佑
Time of Presentaion	Title of Paper	Abstract ID
08:00-08:08	Secretory Carcinoma in Salivary Gland - A case report 唾液腺分泌性癌 - 案例報告 Chih Yao, CHENG 鄭至堯	0310 A1 -24
08:08-08:16	Salvage surgery for the head and neck cancer 頭頸部癌症救援手術 Wan Ting, HUANG 黃莞婷	0310 A2 -63
08:16-08:24	Direct fluorescence visualization-guided surgery to detect clinically occult oral carcinoma: a preliminary serial cases report. Ke Hsiang, SHEN 沈格祥	0310 A3 -66
08:24-08:32	Neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-f luorouracil in oral squamous cell carcinoma patients – an overview of case series and review of papers 紫三醇、順鉑和 5- 氟尿嘧啶於前導性化學藥物治療口腔鱗狀上皮癌患者 – 病例系列回顧及文獻回顧 Chia Chun, HSU 許家浚	0310 A4 -84
08:32-08:40	Carotid blowout syndrome after radiation for head and neck cancer: report of three cases 頭頸癌放射線治療相關之頸動脈爆裂症候群 - 病例報告 Li Chi, LIN 林立綺	0310 A5 -91
08:40-08:48	Technique Note of Modified tie-over method for buccal mucosa by using soft liner material within gloves – an ideal material for impression and stent Jih Yu, CHIU 邱日宥	0310 A6 -95
08:48-08:56	Comparison of virtual surgical planning and actual surgical results in orthognathic surgery : 5-case report Yu Cheng, CHENG 鄭育誠	0310 A7 -13
08:56-09:04	Surgical and orthodontic correction in maxillary constriction adult patient 手術與矯正治療上顎窄縮之成人病患 Che Hung, LIU 劉哲宏	0310 A8 -19
09:04-09:12	Treatment of long standing TMJ dislocation - case report Yi Fan, WU 吳禕凡	0310 A9 -25
09:12-09:20	A Proposal of Treatment Modalities and Management of the Temporomandibular Joint in Rheumatoid Arthritis: Alternatives to Long- term Pharmacotherapy and Joints Replacement Ying Chui,HONG	0310 A10 -57
09:20-09:28	A retrospective study of surgical intervention in treating internal derangement of temporomandibular joint 顳顎關節障礙手術性治療之回顧性研究 Chi Hsueh, YANG 楊其學	0310 A11 -78

Oral presentation
March 10 / Meeting Room B
Moderator: 許文祥 / 陳畊仲
Time of Presentaion	Title of Paper	Abstract ID
08:00-08:08	Cervical Lymphadenopathy of Extrapulmonary Tuberculosis Infection ― A Case Report 病例報告―肺外結核感染的頸部淋巴腫大 Meng Chun, TSAI 蔡孟君	0310 B1 -18
08:08-08:16	Osteosarcoma of the mandible on a patient with McCune-Albright syndrome – Case report Anjelique Marih, FERNANDEZ	0310 B2 -35
08:16-08:24	Management of Fibrous Dysplasia without Surgical Intervention: A Case Report Wilfredo Jr. Morano, DEOCAMPO	0310 B3 -38
08:24-08:32	Juvenile ossifying fibroma - A case report 青少年型骨化纖維瘤 - 病例報告 Nan En, HO 何念恩	0310 B4 -42
08:32-08:40	Extracranial schwannomas arising from rare locations in the head and neck: A report of 2 cases and Literature Review. Gerald Teng Co, HERNANDEZ	0310 B5 -46
08:40-08:48	Mandibular ameloblastoma treated by bone resection and free fibula bone flap reconstruction with 3D virtual planning – a case report 下顎造釉細胞瘤切除後，利用 3D 列印輸出術前診斷模以游離腓骨皮瓣重建― 病例報告 Yu Hsin , TAN 譚玉欣	0310 B6 -56
08:48-08:56	Mammary analogue secretory carcinoma of parotid gland --- A case report and literature review 腮腺類乳腺分泌性癌 --- 病例報告及文獻討論 Han Wei, HUANG 黃瀚緯	0310 B7 -64
08:56-09:04	Antrolith of maxillary sinus with intraoral involvement due to foreign body reaction: Report of a case and literature review 因異物引起之鼻竇結石併口內病灶呈現：個案報告及文獻回顧 Yen Ching, LEE 李晏青	0310 B8 -90
09:04-09:12	Amyloidosis with lymphoepithelial lesion in parotid gland: a case report and literature review Chun Liang, CHANG	0310 B9 -94
09:12-09:20	Robotic surgery for a recurrent dysplastic lesion in base- of-tongue : case report 機械手臂手術於舌根復發性上皮變異之應用：病例報告 Li Nai, CHEN 陳里奈	0310 B10 -22
09:20-09:28	Transoral Robotic Surgery for Left Side Tongue Squamous Cell Carcinoma with Limited Mouth Opening – Case report Jan Michael , ANTES	0310 B11 -33
09:28-09:36	Osteochondroma of the Right Mandibular Condyle: Report of a Case 下顎右側髁突骨軟骨瘤 : 病例報告 Shu Gen, YANG 楊曙亙	0310 B12 -41

Oral presentation
March 10 / Meeting Room C
Moderator: 張明智 / 李芳輝
Time of Presentaion	Title of Paper	Abstract ID
08:00-08:10	Effect of elective neck dissection on prognosis in early stage, N0 tongue squamous cell carcinoma 於早期階段且無淋巴轉移之舌鱗狀細胞癌施行選擇性頸部淋巴廓清術對於預後之影響探討 Yen Cheng, CHEN 陳彥呈	0310 C1 -87
08:10-08:20	Oral cancer in the female patients Yi Wen, CHENG 鄭宜文	0310 C2 -73
08:20-08:30	Potential Risk Factors for Osteoradionecrosis of the Jaws in Oral Cancer Patients-A case-control Study Ting Yun, YEH	0310 C3 -58
08:30-08:40	Expression of ZNF582 and PAX1 genes in oral scraping samples for normal, dysplastic and cancer patients 口腔黏膜抹片中，ZNF582 及 PAX1 基因在正常、上皮變異及口腔癌患者中的基因表現 Chia Ning, HSIANG 項家寧	0310 C4 -26
08:40-08:50	The Significance of Tumor Budding on Oral Cancer Survival and the Relevance in New AJCC Staging System 芽狀癌細胞於新版口腔癌分期系統中對於預後顯著性影響之探討 Yi Yun, HO 何翊芸	0310 C5 -44
08:50-09:00	Prognostic significance of invasion depth in early stage oral tongue squamous cell carcinoma 腫瘤侵犯深度對於早期舌頭鱗狀上皮細胞癌的預後影響 Tsung Wen, YEN 嚴崇文	0310 C6 -86
09:00-09:10	Globo H Expression on Oral Cancer Patients with Cervical Metastasis 腫瘤相關抗原 Globo-H 在頸部淋巴轉移之口腔癌患者上的表現 Chieh Ling,CHIANG 姜潔玲	0310 C7 -27
09:10-09:20	A clinical study of oral cancer in elderly patients aged 75 or older Shoko, KIRIKOSHI	0310 C8 -100
09:20-09:30	Expresison of Transferrin and Transferrin receptor in oral cancer patients Tzu Huan, HUANG 黃子桓	0310 C9 -28
09:30-09:40	Pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinomas 術前利用血漿白蛋白及尿酸濃度搭配身體質量指數評估口腔癌預後 Wei Chin, CHANG 張維晉	0310 C10 -04

E-poster presentation
March 10 / Meeting Room D
Moderator: 黃則達 / 陳玟秀
Time of Presentaion	Title of Paper	Abstract ID
08:00-08:05	Epidermoid cyst developed in forearm flap mimicking tumor recurrence: report of a case of buccal cancer 手前臂饒動脈游離皮瓣移植後形成之表皮樣囊腫 : 病例報告 Shih Bin, GUO 郭仕斌	0310 D1 -43
08:05-08:10	Management of Maxillofacial Gunshot Injury with Severe Tissue Avulsion: A Case Report 嚴重顏面部槍傷處理 : 病例報告 Yuan Kai, KE 葛元楷	0310 D2 -16
08:10-08:15	Denosumab-related Osteonecrosis of the Maxilla - A Case Report Denosumab 相關連之顎骨壞死 - 病例報告 Hsiao Han , HSU 徐筱涵	0310 D3 -74
08:15-08:20	Surgical Approach to Ankylosed Tooth in Assisting Orthodontic Tooth Alignment: Two Case Reports Yi Hua, SUN 孫以華	0310 D4 -69
08:20-08:25	Repeated Carotid Sinus Syncope as a Sign of Oral Cancer Recurrence - A Case Report 反覆的頸動脈竇昏厥為頭頸癌復發之徵兆 - 病例報告 Hou Chiang, CHOU 周厚江	0310 D5 -76
08:25-08:30	A case of osseous choristoma in the dorsum of the tongue Koji, NAKAMATSU	0310 D6 -98
08:30-08:35	Juvenile Sjögren´s syndrome 若年性修格連氏症候群 Makoto, ADACHI 足立誠	0310 D7 -96
08:35-08:40	Chimeric Fibular Free Flap in Oromandibular Reconstruction 複合式腓骨自由皮瓣於口顎部重建的應用 David Wei Kai, HSU 徐偉凱	0310 D8 -45
08:40-08:45	Robotic-assisted Resection of Benign Neck Tumor with Retroauricular Hairline Approach: A Case Report 透過耳後髮際線運用達文西手臂完成頸部腫瘤摘除手術 Po Han, YEN 顏伯翰	0310 D9 -20
08:45-08:50	A case of calcium pyrophosphate dihydrate crystal deposition disease suspected the tumor of temporomandibular joint Masahiro, IWATA 岩田雅裕	0310 D10 -102
08:50-08:55	Outcomes of conservative treatment versus open reduction and internal fixation of mandibular condylar fracture : A retrospective study 比較保守性治療與手術治療下顎骨髁突骨折 ~~ 回溯性研究 Chih Yu, PENG 彭芷瑜	0310 D11 -71

08:55-09:00	Influence of alveolar cleft defect size on the success of monocortical mandibular bone grafting procedure for reconstruction of alveolar cleft Kyoko, YAMAGUCHI	0310 D12 -101
09:00-09:05	Treatment Complication of fibular bone vertical distraction Osteogeneis : A series of case Yang Ming, CHANG 張陽明	0310 D13 -10
09:05-09:10	Influence of tilting of implant and the loading direction on the displacement and micromotion of immediately loaded implants: an in vitro experiment and finite element analysis Tsutomu, SUGIURA 杉浦勉	0310 D14 -23
09:10-09:15	Dynamic navigation implant surgery to restore edentulous ridge:a case series and literature review 導航植牙手術重建缺牙區 : 病例報告與文獻回顧 Chia Jui, LIU 劉珈瑞	0310 D15 -82
09:15-09:20	Pilot study of biphasic bone substitute with precipitatol low crystalline nano hydroxyapatite Yusuke, YAMAGUCHI	0310 D16 -105
09:20-09:25	Evaluation of the novel surface treatment of titanium by electrolyte reduction ion water Takahito, MIKI	0310 D17 -104
09:25-09:30	Clinical significance of up-regulated miR-181a in prognosis and progression of oral cancer Chin Shan, KUO 郭進賢	0310 D18 -54
09:30-09:35	Usefulness of Salivary Auto-antibodies as Diagnostic Adjunct in Oral Precancers and Oral Carcinoma Screening 唾液自體抗體應用於口腔癌早期偵測之探討 Chang Chou, YUAN 袁章洲	0310 D19 -65
09:35-09:40	MALDI-IMS Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Oral Squamous Cell Carcinoma 經蛋白質譜儀影像系統 (MALDI-IMS) 發現 TMSB4X 為口腔癌患者的預後標記 Li Hsing(Tex), CHI 祁力行	0310 D20 -68
09:40-09:45	Promotion of oral management for inpatients in the regional medical center in Japan Shuhei, IWAMOTO	0310 D21 -103
09:45-09:50	Using customized and 3D-printed titanium plate for reconstructive surgery post head and neck osteosarcoma ablation surgery 利用客製化和 3D 列印技術鈦金屬骨板重建頭頸部惡性骨肉瘤切除手術 Nan Ching, LIN 林楠瑾	0310 D22 -31

Oral presentation
March 11 / Meeting Room A
Moderator: 鄭介原 / 陳信銘
Time of Presentaion	Title of Paper	Abstract ID
08:00-08:08	A CASE OF EXTENSIVE AMELOBLASTOMA IN THE MANDIBLE RECONSTRUCTED WITH FREE FIBULA GRAFT UTILIZING 3D DIGITAL TECHNOLOGY Fredeswinda Calvar, MACO	0311 A1 -29
08:08-08:16	A Retrospective study of Fibula Flap over a Ten-year Period 腓骨游離皮瓣十年之回溯性研究 Hao Jhe, LIAO 廖浩哲	0311 A2 -32
08:16-08:24	Perforator Flaps for Head and Neck immediated Reconstruction 穿支皮瓣應用頭頸部術後立即重建 Wen Shian, HSU 許文祥	0311 A3 -34
08:24-08:32	Acute intestinal ischemia after the surgery of oral cancer – a case report 口腔癌術後併發急性缺血性腸疾 - 病例報告 Kung Yu, SHAO 邵孔昱	0311 A4 -37
08:32-08:40	Using Abbe-Estlander flap for lower lip defects involving oral commissure 利用 Abbe-Estlander flap 重建包含嘴角之下唇缺損 Yu cheng, LIU 劉裕誠	0311 A5 -40
08:40-08:48	CAD/CAM surgical guide assisting orthognathic surgery 使用 CAD/CAM 導板輔助正顎手術之進行 Yuan Han, CHANG 張元瀚	0311 A6 -48
08:48-08:56	Reconstruction using a plate prebent with 3-dimensional printing modeling in mandibulectomy patient - a case report Chao Chih, LIU 劉釗誌	0311 A7 -50
08:56-09:04	Simultaneous bilateral deltopectoral flap combined with bilateral Coronoidotomy to release severe truisms: Case report 合併雙側胸肩皮瓣以及喙狀突切開術治療口腔癌術後嚴重張口受限 : 案例報 Tuan Yu, KAO 高端佑	0311 A8 -52
09:04-09:12	Computer-aided mandibular reconstruction 電腦輔助下顎骨重建 Pei Yin, CHEN 陳珮吟	0311 A9 -62
09:12-09:20	Computer-Aided surgical simulation with 3D printing technique in mandible reconstruction—a case report Chi, YEH 葉齊	0311 A10 -70

Oral presentation
March 11 / Meeting Room B
Moderator: 林宏政 / 蘇偉嘉
Time of Presentaion	Title of Paper	Abstract ID
08:00-08:08	Nerve-monitoring system application for left large parotid cyst Tai Long, CHEN 陳泰龍	0311 B1 -36
08:08-08:16	Applications of Rapid Prototyping Teeth Model as Surgical Templates in Autotransplantation 3D 列印輔助自體齒移植之應用 Lisa Alice, HWANG 黃依莉	0311 B2 -55
08:16-08:24	Change position of impacted third molar roots as a new odontectomy method : A retrospective study Yu Li, HUANG 黃郁理	0311 B3 -83
08:24-08:32	Ectopic Eruption of Supernumerary Tooth in Nasal Cavity : Surgical extraction via LeFort I osteotomy case report 鼻腔內異位萌發之贅生齒使用勒佛士第一型截骨術方式拔除 ( 病例回顧 ) Shih Yuan, CHEN 陳世淵	0311 B4 -85
08:32-08:40	Repositioning of the inferior alveolar nerve in cases of severe mandibular atrophy. Two clinical cases and literature review. Kai Hua, LIEN 連凱華	0311 B5 -93
08:40-08:48	Management of the Mandibular Condylar Fractures Using a New Modified Approach 使用新的修改手術途徑治療下顎骨髁骨折 Jain Hao, JHU 朱健豪	0311 B6 -61
08:48-08:56	Traumatic Dislocation of the Mandibular Condyle into the Middle Cranial Fossa Treated With Intraoral Approach: A Case Report 顳顎關節髁頭之創傷異位至中顱窩經口內進路－病例報告 I, CHEN 陳易	0311 B7 -77
08:56-09:04	A Case of Gunshot Injury in A 10-month-old Infant 10 個月大男嬰槍傷 - 病例報告 Yen Lin, CHEN 陳彥霖	0311 B8 -89
09:04-09:12	Excision ameloblastoma in anterior mandible by 3-D printing cutting guide 使用 3-D 列印手術導板於前下顎骨之造釉細胞瘤切除 Pei Jung, CHEN 陳珮蓉	0311 B9 -79
09:12-09:20	Displacement of dental implant into maxillary sinus 牙科植體陷入上顎竇 Hao, SHIH 施皓	0311 B10 -39

Oral presentation
March 11 / Meeting Room C
Moderator: 許博智 / 陳竣峰
Time of Presentaion	Title of Paper	Abstract ID
08:00-08:10	Treatment as early as possible in patient with anti-resorptive agents due to occult osteonecrosis 盡早處理有抑制骨吸收用藥史病人之口內病灶 Kai Yuan, HSIAO 蕭凱元	0311 C1 -21
08:10-08:20	Root Migration Pattern after Third Molar Coronectomy: A Long-term Analysis 牙冠切除術後牙根徒動之長期研究 Ka Yan, CHEUNG 張嘉恩	0311 C2 -75
08:20-08:30	Free buccal fat pad for surgical defect filling of medication related osteonecrosis of the jaws(MRONJ) 使用游離頰脂墊填補藥物相關骨壞死手術缺損 Jen Wei, CHENG 鄭人瑋	0311 C3 -49
08:30-08:40	Rapid return to function after Maxillomandibular advancement in obstructive sleep apnea patient: Optimizing the sagittal split osteotomy 睡眠呼吸中止症病人經顎骨呼吸道拉提手術：如何快速恢復功能 Yu Feng, CHEN 陳裕豐	0311 C4 -88
08:40-08:50	Investigation of prevalence of cystic change for patient with impacted mandibular third molar 阻生第三大臼齒囊腫化盛行率之調查 Tsung Hsun, HO 何宗訓	0311 C5 -80
08:50-09:00	Investigation of Mechanical Properties of Three - dimensional Printed Porous Reconstruction 三維列印多孔重建骨板力學性能探討 Fu Yuan, TENG 鄧富元	0311 C6 -72
09:00-09:10	Mouth-Opening Device as a Treatment Modality in Cancer- related Patients with Trismus: A Prospective Study 新式張口練習裝置於頭頸癌相關張口受限病人之復健治療 - 前瞻性研究 Yu Hsuan, LI 李宇璿	0311 C7 -11
09:10-09:20	Enhanced bone regeneration efficacy of bone morphogenetic protein-2 by the complexation with sulfonated polyrotaxanes. Masahiko,TERAUCHI	0311 C8 -99
09:20-09:30	3D Measurement of the Zygomatic Implant Insertion Length in Zygoma 運用 3D 軟體分析顴骨植體術後在顴骨內的長度 Ting Yu, HUANG 黃婷愉	0311 C9 -17
09:30-09:38	Three-Dimensional Upper Airway Volume Change after Maxillomandibular Advancement in Obstructive Sleep Apnea Patient 運用 3D 軟體分析睡眠呼吸中止症病人接受顎骨前置手術後上呼吸道體積變化 Po Chih, HSU 許博智	0311 C10 -70

Oral presentation
March 11 / Meeting Room D
Moderator: 吳政憲 / 涂曦丰
Time of Presentaion	Title of Paper	Abstract ID
08:00-08:10	How predictable is facial asymmetry correction? Kai Hsin, LEE 李愷忻	0311 D1 -53
08:10-08:20	Unfavorable Fractures During Sagittal Split Ramus Osteotomy: A Risk Reduction Protocol 避免於下顎矢狀骨劈開術造成不良骨裂之建議原則 Yan Chi, CHEN 陳彥綦	0311 D2 -67
08:20-08:30	Intra-articular injection of sodium hyaluronate for the treatment of temporomandibular joint osteoarthritis 玻尿酸治療顳顎關節骨關節炎之研究 Ming Yi, LU 呂明怡	0311 D3 -15
08:30-08:40	Complication Rate of the Reconstruction Plate Used in Oral Cancer Surgery and Reconstruction 口腔癌患者下顎骨重建的併發症分析 Jehn Shyun, HUANG 黃振勳	0311 D4 -12
08:40-08:50	Analysis of preoperative CT angiography for anterolateral thigh flap in maxillofacial reconstruction 前外側大腿游離皮瓣用於顎顏面重建術前電腦斷層血管攝影術之分析 Yu An, LAI 賴佑安	0311 D5 -47
08:50-09:00	Proximal Segment Control of Computer-aided Microvascular Osteocutaneous Flap Reconstruction of Mandibular Segmental Defect 利用電腦輔助游離骨皮瓣重建下顎骨整段切除後口腔缺損之近心截骨段控制分析 Tzu Lun, LIU 劉子綸	0311 D6 -92
09:00-09:10	Application of Carnoy’s Solution as an Adjunct for the Conservative Management for Ameloblastomas in jaw bones – case series report Krystle Marie, ROMILLO 羅晶晶	0311 D7 -60
09:10-09:20	Dentofacial Deformities in Hong Kong: A 10 years’ Evaluation of Prevalence and Treatment in a Major Orthognathic Center Li Ying, LUO 羅麗櫻	0311 D8 -30
09:20-09:30	Clinical Histopathologic Evaluation of Oral Premalignant Lesion in Autofluorescence Camera Application 螢光偵測相機儀應用於口腔癌前病變之臨床病理檢查 Tien En, CHIANG 江天恩	0311 D9 -59
09:30-09:40	Determinants of Length of Hospitalization due to Acute Maxillofacial Infections: a 2012-2015 retrospective analysis in a single hospital 急性顎顏面部感染住院時間的決定因素 : 單個醫院 2012 - 2015 年回顧性分析 Wei Ting, LI 李偉廷	0311 D10 -97