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Osteosarcoma of the jaws in
Koreans: analysis of 26 cases
金亨埈(Hyung-Jun KIM)
Department of Oral and Maxillofacial Surgery, Yonsei University College of
Dentistry, Seoul, Korea
Objective: In order to assess clinical behavior, response to treatment, and factors influencing prognosis of
patients with osteosarcoma of the jaws (OSJ) in Koreans.
Methods: A retrospective study of clinical, pathological, and histological records was undertaken for
26 patients with OSJ treated at the department of Oral and maxillofacial surgery in Yonsei University Dental
Hospital from 1990 to March, 2016.
Result: Out of 26 patients studies, there were 9 men (34.6%) and 17 women (65.4%). Twentyone
of 26 patients had osteosarcoma of the mandible, and 5 of 26 patients had osteosarcoma of maxilla. The
histopathology of OSJ is highly variable, ranging from chondroblastic type (6 patients out of 26), osteoblastic
type (10 patients out of 26), fibroblastic type (2 patients out of 26), to the rare variants like mixed type
and small cell osteoscarcoma types among others. All patients underwent gross total excision and only few
patients underwent the neoadjuvant chemotherapy. Postoperative chemotherapy was given to most of the
patient as adjuvant or in combination with radiotherapy. The overall survival rate was 73.1% with a overall
2-yeaer survival rate of 83.3%. The overall 5-,10-,15-year survival rates in this study were 73.5%, 73.5%,
49%, respectively. Using Kaplan-Meier analysis with log rank tests, the size of tumor (T-stage), and resection
margins were found to affect the survival rate significantly. The chemotherapy was not significantly associated
with improved survival rate.
Conclusion: Surgical resection with clear margin is the most important factor in disease survival. The
role for chemotherapy and radiotherapy in osteosarcoma of the jaws remains controversial, which deserves
further studies.
Curriculum Vitae
Graduated from Yonsei University College of Dentistry and took one year Internship and three year Residency,
and two year Fellowship in Oral and Maxillofacial Surgery at Yonsei University Health System.
Received Doctor of Dental Surgery and Master of Science in Dentistry degrees in Yonsei University and Dr.
med. dent. degree in Ludwig-Maximilians University, Munich, Germany.
Visiting Scholar, Oral and Maxillofacial Surgery, Ludwig-Maximilians University, Munich, Germany. (Oct.
1997 - Sep. 1999)–6–
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Visiting Professor, Institute of Surgical Experiment, Ludwig-Maximilians University, Munich, Germany. (Feb.
2006 - Jan. 2007)
Visiting Professor, Oral and Maxillofacial Surgery, Tokyo Dental College, Japan. (Jun. 2008) Visiting Professor, Oral and Maxillofacial Surgery, Technical University of Munich, Germany. (Oct. 2013) Professor and Chairman in Oral and Maxillofacial Surgery, Yonsei University College of Dentistry. Adjunct Professor in Oral Biology, Yonsei University College of Dentistry Director of Education and Research, Yonsei University Dental Hospital Research Ambassador, German Academic Exchange Service Secretary General, Korean Association of Oral and Maxillofacial Surgeons |
