The inhibition of the malignant potential by targeting tumor cell-derived exosomes in oral squamous carcinoma cells

The inhibition of the malignant potential by targeting tumor cell-derived exosomes in oral squamous carcinoma cells

山本哲也(Tetsuya YAMAMOTO)

Professor and Chairman, Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University

Exosomes are 30-100 nm-sized membranous vesicles, secreted from a variety of cell types into their surrounding extracellular space. Various exosome components including lipids, proteins, and nucleic acids are transferred to recipient cells and affect their function and activity. Numerous studies have showed that tumor cell-derived exosomes play important roles in tumor growth and progression. However, the effect of exosomes released from oral squamous cell carcinoma (OSCC) into the tumor microenvironment remains unclear. In the present study, we isolated exosomes from OSCC cells and investigated the influence of OSCC cell-derived exosomes on the tumor cell behavior associated with tumor development. We demonstrated that OSCC cell- derived exosomes were taken up by OSCC cells themselves and significantly promoted proliferation, migration, and invasion through the activation of the PI3K/Akt, MAPK/ERK, and JNK-1/2 pathways in vitro. These effects of OSCC cell-derived exosomes were obviously attenuated by treatment with PI3K, ERK-1/2, and JNK- 1/2 pharmacological inhibitors. Furthermore, the growth rate of tumor xenografts implanted into nude mice was promoted by treatment with OSCC cell-derived exosomes. The uptake of exosomes by OSCC cells and subsequent tumor progression was abrogated in the presence of heparin. Taken together, these data suggest that OSCC cell-derived exosomes might be a novel therapeutic target and the use of heparin to inhibit the uptake of OSCC-derived exosomes by OSCC cells may be useful for treatment.

Curriculum Vitae

1979-1985 Tokushima University Faculty of Dentistry
1985- Kochi Medical School Hospital
1986- Otsuki Hospital
1987- Instructor, Kochi Medical School Hospital
1993- Senior Lecturer, Kochi Medical School Hospital
2000- Associate Professor, Kochi Medical School Hospital
2002-2003 Visiting Scientist, Medical College of Georgia, USA
2004- Professor and Chairman, Kochi Medical School, Kochi University

Two jaw surgery using CAD/CAM wafer based on soft tissue 3D simulation

Two jaw surgery using CAD/CAM wafer based on soft tissue 3D simulation

富永和宏(Kazuhiro TOMINAGA) 九州歯科大学 Kyushu Dental University The goal of orthognathic surgery is to harmonize optimal aesthetic features with functional occlusion. To achieve this goal, precise morphological and functional analyses as well as optimal planning of the final goal during pre-surgical treatment is mandatory. Additionally, accurate reproduction of the simulated goal during operation is necessary. Conventional pre-surgical planning has been made with 2D cephalometric prediction. However, to achieve optimum aesthetic and occlusal results, 3D planning is going to be necessary. Especially in facial asymmetry cases which need surgical correction of not only pitch and roll but yaw, 3D simulation is mandatory. In this paper, I'm going to present two jaw surgery using intermediate wafer fabricated by CAD/ CAM based on soft tissue 3D simulation in facial asymmetry cases. Gross planning mainly relating the surgical correction of pitch and roll of the maxilla is followed by 2D analyses. The data are introduced to 3D virtual surgery program (SimPlant Pro OMS 10.1; Materialise Leuven, Belgium). Soft tissue surface reconstruction after virtual surgery is visually evaluated by some orthodontists and oral surgeons. Then little by little correction of yaw in the software is tested maintaining facial midline. The repositioning position of the maxilla in the best aesthetic feature judged by evaluators is the final goal of the operation. In this position of the maxilla, intermediate wafer is fabricated using CAD/CAM. This method can eliminate many time-consuming laboratory steps. Additionally it can reduce technical errors derived from manual preparation ie, face bow transfer, manual reposition of the plaster cast etc. I will present the accuracy of the method comparing virtual surgery and CT taken after the operation.

Osteosarcoma of the jaws in Koreans: analysis of 26 cases

Osteosarcoma of the jaws in Koreans: analysis of 26 cases 金亨埈(Hyung-Jun KIM) Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, Korea Objective: In order to assess clinical behavior, response to treatment, and factors influencing prognosis of patients with osteosarcoma of the jaws (OSJ) in Koreans. Methods: A retrospective study of clinical, pathological, and histological records was undertaken for 26 patients with OSJ treated at the department of Oral and maxillofacial surgery in Yonsei University Dental Hospital from 1990 to March, 2016. Result: Out of 26 patients studies, there were 9 men (34.6%) and 17 women (65.4%). Twentyone of 26 patients had osteosarcoma of the mandible, and 5 of 26 patients had osteosarcoma of maxilla. The histopathology of OSJ is highly variable, ranging from chondroblastic type (6 patients out of 26), osteoblastic type (10 patients out of 26), fibroblastic type (2 patients out of 26), to the rare variants like mixed type and small cell osteoscarcoma types among others. All patients underwent gross total excision and only few patients underwent the neoadjuvant chemotherapy. Postoperative chemotherapy was given to most of the patient as adjuvant or in combination with radiotherapy. The overall survival rate was 73.1% with a overall 2-yeaer survival rate of 83.3%. The overall 5-,10-,15-year survival rates in this study were 73.5%, 73.5%, 49%, respectively. Using Kaplan-Meier analysis with log rank tests, the size of tumor (T-stage), and resection margins were found to affect the survival rate significantly. The chemotherapy was not significantly associated with improved survival rate. Conclusion: Surgical resection with clear margin is the most important factor in disease survival. The role for chemotherapy and radiotherapy in osteosarcoma of the jaws remains controversial, which deserves further studies. Curriculum Vitae Graduated from Yonsei University College of Dentistry and took one year Internship and three year Residency, and two year Fellowship in Oral and Maxillofacial Surgery at Yonsei University Health System. Received Doctor of Dental Surgery and Master of Science in Dentistry degrees in Yonsei University and Dr. med. dent. degree in Ludwig-Maximilians University, Munich, Germany. Visiting Scholar, Oral and Maxillofacial Surgery, Ludwig-Maximilians University, Munich, Germany. (Oct. 1997 - Sep. 1999)–6–

Visiting Professor, Institute of Surgical Experiment, Ludwig-Maximilians University, Munich, Germany. (Feb. 2006 - Jan. 2007) Visiting Professor, Oral and Maxillofacial Surgery, Tokyo Dental College, Japan. (Jun. 2008) Visiting Professor, Oral and Maxillofacial Surgery, Technical University of Munich, Germany. (Oct. 2013) Professor and Chairman in Oral and Maxillofacial Surgery, Yonsei University College of Dentistry. Adjunct Professor in Oral Biology, Yonsei University College of Dentistry Director of Education and Research, Yonsei University Dental Hospital Research Ambassador, German Academic Exchange Service Secretary General, Korean Association of Oral and Maxillofacial Surgeons

My Modified Surgical Tips from Original Orthognathic Procedures -Experience-based Suggestion

My Modified Surgical Tips from Original Orthognathic Procedures -Experience-based Suggestion

金 容德教授　(Professor Yong-Deok KIM)

Department of Oral and Maxillofacial Surgery, School of Dentistry,

Pusan National University, KOREA

Orthognathic surgery is procedure designated to correct conditions of the jaw and face related to structure, growth, sleep apnea, TMJ disorders, malocclusion problems owing to skeletal disharmonies or other orthodontic needs. It has been well documented in the numerous texts and very familiar with recent oral and maxillofacial surgeons all around the world. Each step of the procedure is clearly noticed with proper reason and purposes and guaranty the safe surgery. But some surgeons might modify any step for their own object under their experiences and sometimes the modified step was very useful, reliable and reasonable even they were not commented in any text or article. The present presentation would introduce and suggest my tips which were used practically during my orthognathic surgery. The following modified procedures are part of my tips which are going to mention to the audience.

1. Out-fracture of inferior turbinate
2. Intentional fracture of pterygoid plate
3. Swing cinch
4. Effective exposure of descending palatine artery

I don't think those procedures are evidence-based but hope they might be the useful idea or applied to the audience's daily surgery.

Curriculum Vitae
Professor, Dept. of OMFS, School of Dentistry, Pusan National University, KOREA
Head, Dept. of OMFS, Pusan National University Dental Hospital
Director, Institute of Translational Dental Sciences, Pusan National University, KOREA
Director, Institutional Review Board(IRB) of Pusan National University Dental Hospital
Fellow, International Team for Implantology(ITI)
(former) Visiting Scholar, Dept. of 1st OMFS, School of Dentistry, Kyushu University, JAPAN
(former) Postdoctoral Fellow, Dept. of OMFS, Faculty of Dentistry, Univ. of Toronto, CANADA

會員大會Assembly

 17:10 - 17:40 

International Convention Center

Chorus KMU Singers

16:40 - 17:10

高雄醫學大學 聲樂社

Kaohsiung Medical University Singers

陳俊志醫師指揮

Conducted by Dr William Chun-Chih CHEN, DDS

曲目

童年       Childhood        子供時代

苦行的路 Ascentic Road アスケチックロード

台灣        Taiwan            台湾

Rhinoplasy and Orthognathic Surgery on the Patients with Cleft Lip and Palate by Prof Tsuyoshi TAKATO

Rhinoplasy and Orthognathic Surgery  on the Patients with Cleft Lip and Palate 高戶毅(Tsuyoshi TAKATO)  University of Tokyo Hospital, JAPAN

Dept. of Oral and Maxillofacial Surgery Div. of Tissue Engineering JR Tokyo General Hospital

Due to the multidisciplinary approach, the satisfactory results are obtained in the treatment of cleft lip/ palate. 

However, the deformity of nose and maxillomandibular discrepancy in cleft lip/palate patients, has not been solved completely. Our group reported that one of the reasons of the nasal deformity was caused by the deviation of both the septal cartilage and perpendicular plate. Septoplasty and turbinectomy are performed to relieve the obstructed nasal breathing. An adequate-sized piece is cut from the removed cartilage to enforce the columella, which acts as a strut to keep both lower lateral cartilages symmetrical and to create a nasal tip. A common additional request from our Oriental patients is for a narrower nose with a more prominent profile. We prefer the cantilever bone grafting for that purpose. The graft material is the iliac bone. Although the satisfactory results are obtained, the nose that is reconstructed with iliac bone is too hard and some patients experienced the fracture of the grafted bone. Until now, we developed regenerative cartilage for the nose with auricular chondrocytes. The clinical trial has been finished with satisfactory results. Although the poly-L lactic acid scaffold enables auricular chondrocytes to attach and generate cartilage matrix, it has simple shape, limiting the application of this technique to the cartilage defects in other regions. To solve these problems, now we are promoting a project to develop a 3D bioprinter with which cells and growth factors can be injected in addition to scaffold materials. In this project, we will regenerate bone, skin, meniscus, cartilage and knee joint by mimicking both outer shapes and inner structures of native tissues. We are also engaged in research on ear reconstruction using induced pluripotent stem cells (iPS cells). Conventionally, one-stage 2-jaw surgery combining Le Fort I osteotomy and mandibular setback surgery has been used to treat severe maxillomandibular discrepancy in cleft lip/palate patients. In some patients, stable occlusion and a good aesthetic outcome of this method are precluded by the presence of severely contracted soft tissue. Recently, maxillary distraction has been used for midface advancement in such patients. This technique allows the overlying midface to be advanced, because distraction osteogenesis gradually lengthens both the bones and the soft tissues. However, the control of maxillary movement is difficult and the long wearing of outstanding distractors causes psychosocial problems. To overcome these problems, we had developed the two-stage surgery consists of maxillary distraction and mandibular osteotomies.

Curriculum Vitae Career 2017- Present 2011-2017 2001-2017 1996-2017 1992-1996 1989-1992 1987-1989 1985-1987 1983-1984 1979-1983 Education 1973-1979 Director of Hospital of JR Tokyo General Hospital Director of 22nd Century Medical and Research Center Chief of Division of Tissue Engineering Professor of Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of Tokyo Associate Professor of Department of Oral and Maxillofacial Surgery, University of Tokyo Assistant Professor of Department of Oral and Maxillofacial Surgery, University of Tokyo (1990 July - 1991 May Toronto Sick Children's Hospital, Plastic Surgery Division) Chief of Plastic Surgery Division, Shizuoka Sick Children's Hospital Chief of Plastic Surgery Division, Bokuto Metropolitan Hospital Staff of National Cancer Center, Head and Neck Division Residency-Plastic Surgery Division, Tokyo University Hospital and Hyogo Sick Children's Hospital University of Tokyo, Faculty of Medicine (Graduate School)

TW-KR Joint Board Meeting

台韓合同會

한대 합동회

TAOMS-KAOMS Joint Board Meeting

Time: 7:30 -8:30, March 10 ,2018

時間: 2018年3月10日上午7:30- 8:30

시간 : 2018 년 3 월 10 일 오전 7 : 30- 8:30

4F, Jing-Chuen Garden, Ambassador Hotel Kaohsiung

地點: 高雄國賓飯店 4F景春園

장소 : 앰버서더 호텔 카오슝 4F

主持人

l   程 稚盛 監事（國際事務委員會副主任委員・台中榮民總醫院）

Chi-Sheng CHENG (Auditor; Chair in deputy, International Affair Committee; Taichung Veteran General Hospital)

韓國代表 Korean Delegates

Young-Wook PARK朴瑛郁 教授 (President of KAMPR)
 Chul Hwan KIM (President of KAOMS)

 Seung O KO Invited Speaker (Vice President of KAMPRS)

 Yong-Deok KIM Invited Speaker (International Liaison of KAMPRS
金容德 教授 釜山國立大學校

 Hyung Jun KIM Invited Speaker (Secretary Genera l of KAOMS)

 Woong NAM Invited Speaker Planning of KAMPRS

 Kyung-Hwan KWON Invited Speaker Insurance of KAMPRS

 

台灣代表Taiwanese Delegates

  陳 遠謙 理事長 台中 中國醫藥大學

Prof Michael Yuanchien CHEN (President TAOMS, China Medical U, Taichung)

  陳 萬宜 理事（台中榮民總醫院）

Prof Man-Yee CHAN (Council director, Taichung Veteran General Hospital)

  陳 俊明 監事（高雄醫學大學）

Prof Chun-Ming CHEN (Auditor, Kaohsiung Medical U)

  蔡 國陽 理事(彰化基督教病院)

Kuo-Yang TSAI (Council director, Changhua Christian Hospital)
 林 冠州 理事（IAOMS台灣代表／台北萬芳醫院醫學中心）

Charles Kuanchou LIN （Council Director, TPE Municipal WanFang Hospital）
 鄭 世榮 主任委員(學術委員會; 國立台灣大學)

     Prof Elliot Shih-Jung CHENG (Scientific Committee Chair)

     Invited speaker at 59^th KAOMS

  李 曉屏 監事(三軍總醫院/三軍総病院; 國防醫學院)

Shiao-Pieng LEE (Council director, Tri-Service General H, National Defense Medical Center)

 彭 芷瑜 理事 (台中中山醫學大學/台中中山医学大学)

ChiYu PENG (Council director, Chung Shan Medical U, Taichung)

 吳政憲 理事 (國立陽明大學 台北榮民總醫院)

Cheng-Hsien WU (National Yang Ming University, Taipei Veteran General Hospital)

 方致元 主任委員（法制委員會; 台北市立総合医療センター台北萬芳醫院醫學中心）

Chih-Yuan FANG (TPE Municipal WanFang Hospital)

張 明智  秘書長(事務総長；汐止國泰醫院/汐止国泰総合病院)

Ming-Chih CHANG (Secretary in General, Sijhih Cathay General Hospital)

 吳 家佑 理事 (臺北醫學大學/台北医学大学)

Chia-Yu WU (Council director, Taipei Medical U)

 許 博智 監事 (新店慈濟醫學中心／仏教慈済総合病院台北分院)

Po-Chih HSU (Taipei Buddhist Tzu Chi General Hospital
柯 政全 主任委員(國際事務委員會主任委員; 高雄醫學大學)

    Edward Chengchuan KO (International Affair Committee Chair, Kaohsiung Medical U)

Organizing Committee Chair, 2018 Annual Conference of TAOMS 大會籌備會主席

Invited speaker at 59th KAOMS

議程 (Agenda):

1.      Opening welcome message              

Edward Chengchuan KO  (TAOMS國際事務主委/委員長)

2.  Greetings & Introductions by the Presidents (介紹雙方與會成員)         

      Prof Michael Yuanchien CHEN陳 遠謙 理事長&

  Young-Wook PARK (President of KAMPR)

  Chul Hwan KIM (President of KAOMS)

3.      Introduction of Annual Meetings:

 (1)59th Congress of KAOMS, 2018  

  Chul Hwan KIM (President of KAOMS)

会 期：2018年4月26日（Thu）〜 28日（Sat）

会場：Asan Medical Center

Will be held from Apr 26^th-28^th, 2018

Venue: Asan Medical Center

Officially Recommended Speakers from Taiwan will be

鄭世榮 教授 Prof. Shih-Jung CHENG (National Taiwan University)

柯政全      Edward Chengchuan KO (Kaohsiung Medical U)

   (2) Information about 2018 annual meeting of KAMPRS by  

      Young-Wook PARK (President of KAMPRS)

Organizer:

会 期 : 2018年10月25日-27日

会 場 : 大韓民國忠清北道清洲市

      Date: Oct 25- 27^th, 2018

Venue: Cheongju청주시

(3) Information about TAOMS, 2019 by Prof MY CHEN陳遠謙

      2019 TAOMS Will be held in from March 9th-10th, 2019.

      Venue: Fleur de Chine by the Sun Moon Lake

（日月潭雲品溫泉酒店）

      No lectures, no speech, only hot spring and election!!

4.  Information about 2018 ACOMS hosted by TAOMS, by Prof. 陳遠謙

5.  Free discussion

6.  Closing message 

柯 政全Edward Chengchuan KO  (TAOMS國際事務主委)

7.  Group Photo